Epigenetics in heart failure phenotypes

Epigenetics in heart failure phenotypes☆

Chronic heart failure (HF) is a leading clinical and public problem posing a higher risk of morbidity and mortality in different populations. HF appears to be in both phenotypic forms: HF with reduced left ventricular ejection fraction (HFrEF) and HF with preserved left ventricular ejection fraction (HFpEF). Although both HF phenotypes can be distinguished through clinical features, co-morbidit...

Epigenetics, Protein Kinases and Heart Failure

Heart Failure: Advanced Development in Genetics and Epigenetics

Heart failure (HF) is a complex pathophysiological syndrome that arises from a primary defect in the ability of the heart to take in and/or eject sufficient blood. Genetic mutations associated with familial dilated cardiomyopathy, hypertrophic cardiomyopathy, and arrhythmogenic right ventricular cardiomyopathy can contribute to the various pathologies of HF. Therefore, genetic screening could b...

Genetics and epigenetics of arrhythmia and heart failure

Heart failure (HF) is the end stage of several pathological cardiac conditions including myocardial infarction, cardiac hypertrophy and hypertension. Various molecular and cellular mechanisms are involved in the development of HF. At the molecular level, the onset of HF is associated with reprogramming of gene expression, including downregulation of the alpha-myosin heavy chain (α-MHC) gene and...

Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction.

O ver the past 2 decades, the syndrome of heart failure with preserved ejection fraction (HFpEF) received a lot of attention. However, little therapeutic progress was made. Among the issues that may account for the modest therapeutic progress, one appears to be overwhelming: HFpEF is not a well-defined clinical entity: It is an amalgam of cardiovascular, metabolic, renal, and geriatric conditio...